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Connecting mitochondrial biology to therapeutic development

LUTERION's translational research strategy links mitochondrial function, immune-metabolic signaling, and tissue recovery to development-relevant biomarkers.

Live-cell evidence

Watch Lu120819 prime T cells to destroy lung cancer

A direct, side-by-side comparison using immune cells from the same donor. Both panels were imaged by label-free Nanolive holotomography and analyzed with AI-powered digital segmentation — no fluorescent labels. The only difference between the panels is Lu120819.

Nanolive holotomography · AI digital segmentation · 450×450 µm · 24 h Nanolive holotomography · LIVE T Cell Assay · 36 h endpoint
© LUTERION · Unauthorized use prohibited
Left — Control (healthy PBMC)
Right — PBMC pre-treated with Lu120819
A549 target cells
T cells
Interaction points
Apoptotic (dying) cells

Label-free holotomography with AI digital segmentation (Nanolive LIVE T Cell Assay). A549 target cells (blue), T cells (red) and their interaction points (yellow). 450×450 µm field · 4-min intervals · recorded over 24 h.

Label-free holotomography with apoptosis segmentation (magenta) and automated EVE analytics. Endpoint quantification at 36 h.

Endpoint at 36 hours · 10×10 grid
Control — healthy PBMC
372 target cells remaining
No target cell death observed
Lu120819 — pre-treated PBMC
172 target cells remaining
Apoptotic cell death observed
T cell count rose 256 → 339

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These recordings are a window into our host-directed immuno-oncology program. Partners and investors can request a detailed scientific review.

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Across its research programs, the company evaluates biological readouts related to mitochondrial activity, cellular stress responses, immune function, and tissue remodeling. These translational approaches are designed to support nonclinical development, clinical planning, and indication-specific development decisions while preserving key proprietary data.

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Mitochondrial function

Development-relevant readouts related to mitochondrial activity and cellular energy regulation.

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